3a Montpelier Street, Knightsbridge, London, SW7 1EX 020 7584 4777
[email protected]
Book now

Polynucleotides Treatment London

at Omniya Clinic in London

Polynucleotides are one of the most exciting advances in regenerative aesthetics. Unlike traditional fillers that only restore lost volume, polynucleotide injections work at a cellular level to repair, hydrate and strengthen your skin from within. The result? Firmer, smoother, more radiant skin that looks healthy and natural, not overdone.

Treatment overview

  • Procedure time: 30 minutes
  • Sessions recommended: 2–3, spaced 2–3 weeks apart
  • Downtime: Minimal to none
  • Results: Visible within weeks, optimal at 2 months
  • Duration: 6–9 months
  • Price: From £350

 

What Are Polynucleotides?

Polynucleotides are long chains of nucleotides – the natural building blocks of DNA and RNA. In aesthetics, they are usually derived from purified salmon DNA, chosen for its remarkable biocompatibility with human tissue.

When injected into the skin, polynucleotides work in several ways:

  • Stimulating fibroblasts, the cells responsible for producing collagen and elastin.
  • Encouraging cellular repair and regeneration, helping skin recover from stress and damage.
  • Providing deep hydration by binding to water molecules and improving skin elasticity.
  • Reducing inflammation and oxidative stress, protecting skin at a cellular level.

 

Unlike traditional fillers, which focus on restoring lost volume, polynucleotides target the health and structure of the skin itself. This restorative approach improves tone, texture, and radiance over time, making it an ideal option for patients seeking natural, long-term rejuvenation.

Injectable moisturiser polynucleotides dr Mariam

How Do Polynucleotides Work as Skin Boosters?

Polynucleotides (PN) are often described as next-generation skin boosters — but they do far more than hydration. Their bioactive properties target the skin at a cellular level, delivering both cosmetic and regenerative benefits.

Clinical studies show polynucleotides can increase collagen production by up to 47% within 23 days. By activating fibroblasts - the cells responsible for collagen and elastin - they strengthen the skin’s structure for firmer, more youthful results.
Research demonstrates a 52% increase in epidermal density, creating skin that is thicker, more resilient, and less prone to damage over time.
Thanks to their water-binding properties, PN molecules draw and hold moisture in the skin matrix. The result is smoother texture, improved elasticity, and a fresh, dewy glow.
Polynucleotides naturally reduce redness and irritation, making them suitable for sensitive skin types and conditions such as rosacea.
By supporting fibroblast growth and tissue renewal, PN speed up wound healing and improve the appearance of scars, stretch marks, and fine lines.
They also help neutralise free radicals, protecting against oxidative stress and slowing down the impact of environmental ageing.

Together, these actions make polynucleotides a powerful option for comprehensive skin rejuvenation — improving tone, texture, and radiance while building long-term skin health.

polynucleotide skin boosters being injected

Treatment Areas

Polynucleotide injections can be used almost anywhere skin shows signs of ageing or stress, including delicate regions unsuitable for other injectables:

  • Under-eyes (dark circles, hollows, puffiness)
  • Cheeks
  • Neck & décolletage
  • Hands & arms
  • Scalp (for hair and skin health)

 

dr nora consulting with a patient

Benefits of Polynucleotide Treatments

Polynucleotides are particularly effective in areas where the skin is thin, crepey, or prone to volume loss. Popular treatment zones include the under-eye area, cheeks, neck, décolletage, and even the scalp.

  • Smooths fine lines and wrinkles
  • Improves skin tone and texture
  • Minimises acne scars and stretch marks
  • Brightens dark circles
  • Reduces puffiness and crepey skin
  • Restores hydration and elasticity
  • Suitable for sensitive or rosacea-prone skin

 

Note: Polynucleotide treatments contain fish-derived ingredients and are not suitable for vegetarians, vegans or individuals with fish allergies. The treatment is not recommended during pregnancy or breastfeeding.

dr Shahd performing polynucleotide treatment on a patient

Polynucleotide Before & After

What Happens At My Polynucleotides Treatment?

At Omniya Clinic we create a bespoke treatment plan for each patient’s individual skin concerns. Our process is:

  1. Consultation: Your journey starts with a consultation to assess your skin and see if polynucleotide treatment is right for you.
  2. Personalised Skin Assessment: During your consultation, our practitioner will conduct a detailed assessment of your skin quality, examining texture, elasticity, hydration and signs of ageing or damage.
  3. Custom Treatment Plan: Based on your skin assessment, your practitioner will discuss how polynucleotides may address concerns, if they are suitable for you and the course of action. Typically, a course of three treatments 2-3 weeks apart is recommended for best results.
  4. Medical History Review: As with any procedure at Omniya, your practitioner will carefully review your medical history to ensure the treatment is safe and appropriate for you.
  5. Procedure: The polynucleotide solution is injected into the targeted areas using fine needles or blunt-tipped cannulas. The whole treatment takes around 20-30 minutes.
  6. Aftercare: Post treatment instructions will be given to get the best results. Mild redness or puffiness may occur but will subside in a few days.
  7. Follow-Up: To maintain your results follow up treatments every 6-9 months are usually required.

 

polynucleotide consultation room in knightsbridge London

Polynucleotide Results & Expectations

In our extensive experience, we expect to see improvements in skin texture and hydration immediately after treatment but the full benefits will develop over the next 60 days. Results last around 6-9 months depending on individual factors and skin concerns.

Many patients notice improvements in skin texture and hydration soon after treatment. The skin often appears more radiant and feels smoother even after the first session.
While initial results are visible quickly, the full benefits develop progressively over the next 60 days as the polynucleotides stimulate your body's natural collagen production and cellular regeneration processes.
Results typically last around 6-9 months, depending on individual factors such as age, lifestyle, and specific skin concerns. Many of our London patients report continued improvement in skin quality even after the treatment effects have technically subsided
Our Knightsbridge clinic consistently records high satisfaction rates among polynucleotide patients, with many reporting that the treatment exceeded their expectations for natural, youthful-looking skin without an artificial appearance.
Injectable moisturiser polynucleotides dr Mariam

Polynucleotides For Hair and Eye Improvements

The regenerative properties of polynucleotides are showing promise in addressing hair loss:
  • Scalp Health: Polynucleotides can improve the health of the scalp, creating an optimal environment for hair growth.
  • Hair Follicle Stimulation: By enhancing collagen production and promoting cellular turnover, polynucleotides may contribute to stronger, healthier hair growth.
  • Perimenopausal Hair Loss: This treatment can be particularly beneficial for perimenopausal women experiencing hair thinning or loss.
The regenerative properties of polynucleotides are showing promise in addressing under-eye concerns:
  • Skin Quality: Polynucleotides can improve the health and quality of the delicate under-eye skin, creating a more youthful appearance.
  • Collagen Stimulation: By enhancing collagen production and promoting cellular turnover, polynucleotides may contribute to firmer, more resilient under-eye skin.
  • Dark Circles: This treatment can be particularly beneficial for individuals experiencing dark circles due to thin or translucent skin under the eyes.
  • Hydration: Polynucleotides attract and retain moisture, helping to plump and hydrate the under-eye area, reducing the appearance of fine lines.
Ameela Polnucleotides Face rejuvenation before and after image

Why Choose Omniya Clinic London for Your Polynucleotide Treatment?

  • Expert Practitioners: Our team are highly experienced in skin boosters and polynucleotide treatments.
  • Customised Approach: Every treatment plan is tailored to your individual skin concerns and goals.
  • State of the Art Products: We use only the latest and highest quality polynucleotide products including Ameela®, known for its PDRN Salmon DNA, exceptional purity and regenerative properties.
  • Holistic Care: We integrate your polynucleotide treatment with a full skin health approach for long term results and overall skin improvement.

 

At Omniya Clinic we are constantly updating our knowledge and skills in aesthetic medicine so you get the latest and best treatments.

Ameela Polynucleotide Eye Rejuvenation before and after

Overview of Polynucleotides Treatment

varies per patient

Time icon

Procedure time

30 minutes

treatment price graphic

Treatment price

From £350

number of sessions icon

Number of sessions

2-3 treatment

timeframe for results graphic

Timeframe for results

2 weeks

down time icon

Downtime

None

back to work icon

Back to work

Same day

duration icon

Duration of results

6+ months

Treatments Performed by

Polynucleotides FAQs

What is a polynucleotide injectable treatment?

A polynucleotide injectable treatment is a regenerative skin booster designed to improve the health and appearance of your skin from within. Polynucleotides are DNA fragments that, when injected, stimulate your skin’s natural repair processes. They encourage collagen and elastin production, enhance hydration, and reduce inflammation — all of which lead to firmer, smoother, and more radiant skin.

Unlike treatments that simply add volume, polynucleotides focus on strengthening and rejuvenating your skin at a cellular level for long-lasting, natural results.

Are Polynucleotides right for me?

Polynucleotide treatments offer a versatile solution for those seeking to smooth out fine lines and wrinkles, combat early signs of ageing, revive dehydrated skin, correct pigmentation, even out skin texture, or diminish scarring and under-eye concerns such as puffiness and dark circles. To ensure the treatment is tailored to your unique needs, a consultation with your physician is essential to identify the most suitable treatment approach for you.

For more information on whether Polynucleotides are right for you, please review our contraindications, pre- and post- treatment advice page.

How many sessions of Polynucleotides will I need?

The effects of each session can be seen for several months, we recommend 2 to 3 sessions over a 3-week period. We also advise maintenance treatments every 6 to 9 months.

How long will results last?

The rejuvenating effects of polynucleotide treatments are long-lasting, with maintenance sessions recommended every 6-9 months for enduring skin health and vitality. Regular treatments can provide more noticeable and long-lasting results

Are Polynucleotides safe for all skin types?

Yes, the polynucleotide treatments used at Omniya Clinic are biocompatible and safe across various skin types and conditions. During your appointment, your practitioner will have a thorough consultation with you to ensure you are suitable for the treatment.

What makes Ameela the superior polynucleotide option?

Ameela was the first to market, and it stands out due to its potent combination of PDRN Salmon DNA, purity, moisturising power, and ability to target free radicals and regenerate tissue.

How do polynucleotide injections help with skin elasticity loss?

Polynucleotide injections work by activating fibroblasts – the skin cells responsible for producing collagen and elastin. By boosting these structural proteins, the treatment helps firm and strengthen the skin, improving elasticity and resilience. Over time, this reduces the appearance of sagging and creates a more lifted, youthful look.

Are polynucleotide treatments suitable for sensitive skin?

Yes, polynucleotide treatments are generally suitable for sensitive skin, but it’s always best to consult with your practitioner to tailor the treatment to your skin.

Can polynucleotide injections be used under the eyes?

Yes. Polynucleotide injections can be used under the eyes to refresh tired eyes, reduce dark circles and fine lines for a brighter more youthful look.

What can polynucleotides be combined with?

Polynucleotides work well with other aesthetic treatments, like dermal fillers. They can help to harmonise the face while refining skin texture and tone.

What are the regenerative benefits of polynucleotide treatments?

Polynucleotide treatments support the skin’s natural cell regeneration, to improve texture, resilience and overall skin quality over time.

How do polynucleotide injections improve skin texture?

By stimulating collagen and elastin production polynucleotide injections smoothes out the skin, reduces fine lines and revives dull or rough skin.

Who should perform polynucleotide skin rejuvenation treatments?

Polynucleotide treatments should be performed by an experienced medical professional to get the best results and safety.

Can I go back to my normal activities after a polynucleotide treatment?

Yes, most patients can go back to their normal routine soon after treatment as polynucleotide injections have minimal downtime.

What is the difference between polynucleotides and dermal fillers?

Polynucleotides and dermal fillers are both popular aesthetic treatments, but they work in very different ways. Dermal fillers are designed to add or restore volume, instantly sculpting and defining facial contours for noticeable results straight after treatment.

Polynucleotides, on the other hand, take a more regenerative approach. Instead of adding volume, they stimulate your skin’s natural healing processes. This boosts collagen and elastin production, improves skin quality, and enhances hydration. The results develop gradually over 2–8 weeks, giving a subtle, natural-looking rejuvenation that continues to improve over time.

In short:

  • Dermal fillers excel at structure and definition.
  • Polynucleotides focus on long-term skin health and natural radiance.

What is the difference between polynucleotides and Botox?

Polynucleotides and Botox are both effective treatments, but they target ageing in very different ways.

  • Polynucleotides improve the quality and structure of the skin itself. They stimulate collagen production, boost elasticity, and enhance moisture retention, leading to healthier, firmer, and more radiant skin over time.
  • Botox, on the other hand, works on the underlying muscles. By relaxing the muscles that cause expression lines, Botox smooths dynamic wrinkles (such as frown lines or crow’s feet) and delivers quick, reliable results.

 

In simple terms:

  • Botox is best for reducing movement-related wrinkles.
  • Polynucleotides focus on skin health, texture, and long-term rejuvenation.

Can polynucleotides be combined with other treatments?

Yes – polynucleotides are often combined with other aesthetic treatments to achieve more comprehensive results. While polynucleotides work to regenerate and improve the quality of your skin, complementary treatments can target specific concerns:

  • Dermal fillers add or restore volume where it’s needed most.
  • Botox relaxes overactive muscles, softening dynamic wrinkles and expression lines.
  • Chemical peels resurface the skin, improving tone, texture, and clarity.

 

By combining these approaches, you can address multiple aspects of ageing at once – from skin quality and hydration to volume loss and fine lines – for a more balanced, natural-looking outcome.

How do polynucleotides compare to Profhilo and dermal fillers?

Profhilo and hyaluronic acid fillers are well-known for adding hydration and volume. Profhilo spreads through the skin to deliver an all-over boost of moisture, while fillers are used to sculpt and restore lost volume.

Polynucleotides work differently. Rather than focusing on plumping, they stimulate tissue repair at a cellular level, encouraging collagen and elastin production. This makes them especially effective for delicate areas, such as around the eyes, or for patients looking for gradual, long-term skin quality improvements rather than temporary fullness.

At Omniya Clinic, we often combine polynucleotides with treatments like Botox, Profhilo, or dermal fillers to create a tailored plan that addresses both immediate concerns and long-term skin health.


As featured in

Itv logoMetro IconGQ logoBazaar logoThe SunDaily Mail

Proud members of

royal college of surgeons of england logogeneral medical council logogeneral pharmaceutical council logologo-carequalitylogo bdnglogo baaps

Latest news & articles

doctor discussing TRT results and treatments with patients at Omniya Clinic A Patient’s TRT Journey

Hormone & Fertility | 10 September 2025

BBL laser Moxi Laser treatment London. Close up of BBL treatment at Omniya during the process. bbl laser london, moxi laser, bbl laser, bbl and moxi, bbl moxi, bbl moxi london, bbl moxi laser, bbl hero london, bbl hero, bbl and moxi laser, bbl treatment, bbl facial, bbl facial London, moxi laser near me, bbl & moxi HALO: Contraindications, Pre-Care and Post Care Instructions

Care Instructions & Suitability | 29 August 2025

power brows result of a patient at Omniya Clinic London Powder Brows: Safety, Preparation and Aftercare Advice

Care Instructions & Suitability | 25 July 2025

Omniya Clinic London - Image of the interior of Omniya

Free consultations available with our experts*

During your consultation, we will advise you on the best treatments and products to use at home.

*Available with participating practitioners

Book Now
Call Us