What Are Polynucleotide Skin Boosters?
Polynucleotide skin boosters are gaining attention as one of the most effective regenerative treatments in advanced aesthetics. While hyaluronic acid fillers and hydrating injectables like Profhilo have transformed skincare, polynucleotides take things a step further - stimulating your skin to heal and renew itself from within.
At Omniya Clinic in London, we offer polynucleotide injections as part of our commitment to regenerative aesthetics. These treatments improve skin tone, texture, hydration and elasticity - all without adding unnatural volume or stiffness. This guide explains how polynucleotide boosters work, what makes them different, and whether they may be right for your skin concerns.
How Do Polynucleotide Skin Boosters Work?
Stimulating Collagen and Elastin
Polynucleotides are fragments of purified DNA, often derived from salmon. Once injected, they stimulate fibroblasts in the skin - the cells responsible for collagen and elastin production. This collagen boost helps improve the skin’s structure, making it firmer, more elastic, and more youthful in appearance.
Supporting Skin Repair and Hydration
In addition to stimulating collagen, polynucleotides act as antioxidants. They scavenge free radicals and reduce inflammation, helping to repair damaged skin. These injectables also attract water molecules, contributing to deep hydration and improved skin plumpness without the gel-like texture of dermal fillers.
Promoting Cellular Turnover
Unlike many other injectables, polynucleotides stimulate tissue repair at a cellular level. This means your skin doesn’t just look better – it functions better, too. Over time, this can lead to a more resilient skin barrier, improved healing responses, and stronger dermal structure.
Explore how polynucleotide injections support natural skin renewal
Benefits of Polynucleotide Skin Boosters
Improves Texture, Glow, and Elasticity
Patients notice visible improvements in skin texture, hydration and firmness within weeks. The treatment is especially popular among those with dull, tired, or crepey skin - offering a subtle yet effective rejuvenation that builds gradually over time.
Safe for Delicate Areas
Unlike fillers, polynucleotides can be used around the eyes, mouth, and other delicate areas. At Omniya, we often use Ameela Polynucleotides under the eyes to help with dark circles, puffiness, and skin thinning.
Read how polynucleotides target under-eye concerns
Restores Skin After Inflammation or Damage
Polynucleotide boosters are also effective for post-acne scars, sun damage, and inflammatory skin conditions. By encouraging healthy cellular turnover, they help to soften scarring and improve overall skin quality.
Suitable for Men and Women
Polynucleotides are not just for women seeking youthful glow. At Omniya, we increasingly see men using them to tackle tired-looking skin, texture irregularities and signs of ageing, without the stigma or dramatic changes associated with traditional cosmetic procedures.
Read more on the full benefits of polynucleotide therapy
Are Polynucleotides the Same as Other Skin Boosters?
Polynucleotides vs Profhilo
Both are injectable treatments that improve hydration and skin quality, but the key difference lies in their mechanism. Profhilo uses hyaluronic acid to hydrate and stimulate collagen to a modest degree. Polynucleotides are biologically active and work deeper, promoting tissue repair, reducing oxidative stress, and improving the skin's regenerative capacity.
Polynucleotides vs Dermal Fillers
Dermal fillers are designed to replace volume. Polynucleotides are not volumising. Instead, they focus on the quality and integrity of your skin. They are ideal for people who want to avoid the 'overfilled' look or are not ready for volume restoration.
Polynucleotides vs Traditional Skin Boosters
Traditional skin boosters, such as mesotherapy or vitamins, tend to offer surface-level hydration or antioxidant delivery. Polynucleotides, in contrast, trigger your own body to regenerate tissue, offering deeper and more sustained results. Think of them as a signal to your skin to repair and thrive, not just a topical hydration boost.
Find out if polynucleotides are right for your skin goals
Who Can Benefit From Polynucleotide Treatments?
- Patients aged 30+
- Those with dull, thin or dehydrated skin
- People with fine lines or loss of elasticity
- Patients recovering from acne, rosacea or UV damage
- Individuals looking for non-volumising facial rejuvenation
- Men seeking natural skin improvement
Polynucleotides are suitable for most skin types, including sensitive skin. At Omniya, we carry out a full consultation before recommending any injectable treatment.
What are polynucleotides? Discover the science behind them
How Many Treatments Will I Need?
Initial Course
Most patients require 2 to 3 sessions spaced 2-3 weeks apart. This gives your skin the right stimulus over time to activate collagen and repair pathways.
Maintenance
Top-up treatments are recommended every 6-9 months to maintain results. Some patients choose to alternate polynucleotides with Profhilo, Botox or other injectables depending on their needs.
See our full pre- and post-treatment advice guide
Learn more about treatment planning at Omniya Clinic
Can You Combine Polynucleotides with Other Treatments?
Yes - polynucleotides can be part of a personalised treatment plan. Many of our patients combine them with microneedling, PRP, LED light therapy, or hyaluronic acid boosters for a multi-layered approach. Combination therapy allows us to target the skin from different angles - hydration, firmness, regeneration - and optimise your results.
Are There Any Side Effects or Downtime?
Polynucleotide injections are very well tolerated. Mild swelling or redness may occur at the injection sites but usually resolves within 24-48 hours. Bruising is uncommon but can occur in sensitive areas. Patients typically return to normal activities the same day.
As they are made from DNA fragments, they are naturally broken down by the body and carry a very low risk of adverse reaction.
Why Choose Omniya Clinic for Skin Boosters in London?
At Omniya Clinic, we specialise in non-surgical aesthetic medicine and regenerative treatments. Our expert doctors have extensive experience using polynucleotides to restore skin health with subtle, elegant results.
We only use clinically approved brands like Ameela, and all treatments are performed in our medical clinic in Knightsbridge.
We focus on science-backed, bespoke skincare plans that respect the natural integrity of your skin while delivering noticeable improvements.
Book your consultation for polynucleotide skin boosters
Frequently Asked Questions
How long do results last?
Around 6 to 9 months depending on skin quality and number of sessions.
Do polynucleotides add volume?
No. They improve texture and hydration but are not volumising like fillers.
Are polynucleotides good for the under-eye area?
Yes - especially Ameela, which is specifically designed for delicate periorbital skin.
How soon will I see results?
Some notice improved glow within a week, with continued benefits over the following 4 to 6 weeks.
Are they safe for sensitive skin?
Yes. Polynucleotides are biocompatible and anti-inflammatory, making them an excellent choice for patients with rosacea or reactive skin.
Click here to learn more about our polynucleotide services
Book Your Consultation Today
Are you ready to experience the regenerative power of polynucleotide skin boosters? Let our expert team guide you to the right approach for your skin.
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