What Are Polynucleotides?

What are Polynucleotides?

Polynucleotides (PN) are the new buzz in aesthetic medicine. They are a naturally occurring chain of molecules, providing a novel way to rejuvenate the skin. In aesthetic medicine we use highly purified PNs from salmon DNA which is very similar to human DNA. This allows these molecules to bind to your skin cells and trigger a cascade of benefits.

This article explains the science behind these molecules and how they work in skin care.

What are the Components of PNs?

The structure of PNs consists of:

1. Nucleotide units
2. A phosphate group forming the backbone
3. A sugar molecule (deoxyribose in DNA, ribose in RNA)
4. Nitrogenous bases (adenine, guanine, cytosine, and thymine or uracil)

This structure provides the framework to understanding how PNs are applied in skin rejuvenation:

1. Biocompatibility: The structure is similar to human DNA, allowing PNs to interact with skin cells. This is crucial for their effectiveness and safety in skin treatments.
2. Cellular Interaction: The structure of PNs enables them to bind to activate receptors on skin cells, particularly fibroblasts. This interaction is the foundation of their regenerative effects.
3. Hydration Properties: The phosphate groups and sugar molecules in the structure attract and bind water molecules, contributing to the hydrating effect of PN treatments.
4. Building Blocks for Repair: As fundamental components of DNA and RNA, these structures provide the building blocks necessary for cellular repair and regeneration.
5. Antioxidant Action: The structure of PN allows them to act as antioxidants, protecting skin cells from free radical damage.
6. Stimulation of Collagen and Elastin: The specific arrangement of nucleotides can trigger cellular processes that lead to increased production of collagen and elastin.
7. Versatility: The varied components in the structure (phosphate groups, sugar molecules, nitrogenous bases) allow PNS to perform multiple functions in skin rejuvenation.

The above highlights their ability to interact with skin cells, stimulate regeneration, provide hydration, and offer protection against environmental damage. This action, rooted in their molecular structure, is what makes PNs a unique and powerful tool in aesthetic medicine.

What do Polynucleotides do?

PNs work at a cellular level, binding to specific receptors on fibroblast cells. This activation triggers a series of benefits:

1. Fibroblast activation
2. Collagen and elastin production
3. Hydration
4. Antioxidant protection
5. Anti-inflammatory

"PNs are a total skin rejuvenation solution, addressing multiple signs of ageing at once”, lead aesthetician at Omniya Clinic.

Are PNs a Skin Booster?

Yes, they are, and not to be mistaken with dermal fillers (which they often are). Unlike dermal fillers that add volume to specific areas, PNs work to improve the overall condition of your skin. They rejuvenate the skin, by stimulating natural regeneration, resulting in better skin texture, tone and overall appearance.

What are the Benefits of PNs in Skincare?

Benefits of PNs as a skin booster:

• Hydration
• Elasticity
• Fine lines and wrinkles reduction
• Skin texture and tone
• Radiance
• Long term results
• Inflammation and redness reduction
• Wound healing

How do PNs Work in Skin Rejuvenation?

PNs work through:

1. Collagen and Elastin Stimulation: They increase production of these proteins for better skin firmness and elasticity.
2. Hydration: PNS attract and bind water molecules for deep hydration.
3. Cellular Regeneration: They create an environment for fibroblast growth, essential for tissue repair and regeneration.
4. Antioxidant Protection: PNs protect the skin from free radicals.
5. Anti-inflammatory: They reduce skin inflammation for overall skin health.

Will PNs Get Rid of Wrinkles?

PNs can reduce the appearance of fine lines and wrinkles by stimulating collagen production and improving skin elasticity. They won’t get rid of deep set wrinkles but they can:

• Improve overall skin texture
• Firm skin
• Reduce fine lines depth
• Give a more youthful look

How Long do PNs Take to Work?

The effects of polynucleotide treatments develop gradually as they stimulate your skin’s natural regeneration. Some improvements may be visible in a few weeks, optimal results are visible after 2-3 months. Here’s a general timeline:

• Immediately after treatment: Initial plumping due to hydration
• 2-4 weeks: Hydration and radiance
• 4-8 weeks: Visible skin texture and firmness improvement
• 2-3 months: Optimal results with overall skin quality improvement

What Scientific Research Supports PNs?

Scientific research has shown:

1. A study in the Journal of Drugs in Dermatology found PN treatments improved skin hydration and elasticity.
2. Research in the Aesthetic Surgery Journal showed PN increased collagen production by 47% in 23 days.
3. A clinical trial in the Journal of Cosmetic Dermatology found PN treatments resulted in 52% epidermal thickness increase in 23 days.

These studies prove polynucleotides work in skin rejuvenation.

At Omniya Clinic we are committed to providing you with the latest and best treatments available. PNs are part of the current, and likely future of aesthetic medicine, as a natural and biocompatible solution to your skin concerns.

Book a consultation with our team today and start your journey to radiant skin.

FAQs

What do polynucleotides do to the skin?

Polynucleotides work to rejuvenate the skin at a cellular level. They bind to specific receptors on skin cells, particularly fibroblasts, which play a role in collagen production. This interaction promotes skin regeneration, hydration, and resilience, reducing the appearance of fine lines, improving texture, and enhancing radiance.

Is polynucleotide better than Botox?

Polynucleotides and Botox serve different purposes, so “better” depends on your goals. Botox targets muscle movement to smooth wrinkles, often in areas like the forehead or around the eyes. Polynucleotides, on the other hand, work on the skin's structure, focusing on cellular repair and hydration to improve overall skin quality. For a fuller rejuvenation effect, some patients combine the two treatments.

Are polynucleotides better than Profhilo?

Both polynucleotides and Profhilo aim to enhance skin quality but in different ways. Profhilo hydrates and firms the skin by dispersing hyaluronic acid, which provides an instant “glow.” Polynucleotides, meanwhile, work more gradually, focusing on long-term skin health by promoting collagen and elastin production. Depending on your needs—immediate hydration versus deep cellular repair—either treatment could be a good choice, or they can be used together for a layered approach.

What is the function of polynucleotides?

Polynucleotides are designed to improve skin health and appearance by working at a cellular level. They support collagen production, enhance hydration, reduce inflammation, and offer antioxidant protection. These benefits make polynucleotides highly versatile for treating a range of skin concerns, from fine lines and wrinkles to overall texture and elasticity.

Can polynucleotides lift jowls?

Polynucleotides primarily work to improve skin quality, texture, and firmness rather than provide a lifting effect. While they may subtly firm the skin over time, especially around the jawline, they don’t produce the same lifting effect as more targeted treatments, such as dermal fillers or skin-tightening procedures. They can, however, be an excellent addition to a treatment plan for maintaining youthful skin and supporting other lifting treatments.

What are the side effects of polynucleotides in aesthetics?

The treatments are generally well-tolerated, as the molecules are biocompatible and similar to human DNA. Mild side effects may include slight redness, swelling, or bruising at the injection site, which typically subside within a day or two. Serious side effects are rare but can be minimized by having the treatment performed by an experienced clinician.

What are the side effects of polynucleotides for rosacea?

For rosacea, the treatment may actually offer benefits due to their anti-inflammatory properties. Mild redness or swelling can occur initially, as with most aesthetic treatments, but this usually resolves within a few hours to a day. Since polynucleotides help calm inflammation, they’re often well-suited for rosacea-prone skin, helping to reduce redness and improve skin resilience over time.

Can I have polynucleotides after Botox?

Yes, they can be combined with Botox. Many patients choose to have both treatments, as they address different skin concerns. Botox smooths expression lines, while polynucleotides work beneath the skin surface to rejuvenate and improve skin texture. Your clinician can help you time treatments for optimal results.

How quickly do polynucleotides work?

The effects of polynucleotide treatments build gradually. Initial hydration and plumping can be noticeable within a few days, while deeper benefits, like improved skin texture and firmness, develop over 2-3 months as collagen production increases. This steady, natural progress provides lasting results that continue to enhance over time.

What not to do after polynucleotides?

After polynucleotide treatment, it’s best to avoid direct sun exposure, intense physical activity, and hot environments (like saunas) for at least 24 hours. Additionally, avoid applying makeup or any potentially irritating skincare products to the treated area until any initial redness or swelling has settled. Following these steps will help ensure you get the most out of your treatment.