Low Mood HRT and TRT Treatments | Omniya Clinic London

Feel balanced, motivated and more like yourself again at Omniya Clinic, Knightsbridge.

Feeling “not yourself”; flat, irritable, unmotivated or overwhelmed, is common, and it’s often treatable. Low mood can develop gradually or appear after periods of stress, illness or hormonal change.

At Omniya Clinic in Knightsbridge, our doctors take a medical, root-cause approach to understanding your symptoms. Low mood may stem from hormonal imbalance, thyroid dysfunction, nutrient deficiencies, poor sleep, chronic stress, medications, or other underlying health conditions.

Rather than simply coping, we help you understand what’s driving your mood changes and create a tailored plan to support emotional, hormonal and physical balance, so you can feel clearer, calmer and more like yourself again.

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What Is Low Mood?

Low mood refers to a persistent dip in emotional wellbeing. You may feel sad, flat, anxious, or less motivated than usual. Everyday activities might feel harder, and things you normally enjoy may bring less satisfaction.

It’s common to also experience poor sleep, brain fog, low energy, irritability, or changes in appetite. While stressful life events can contribute, ongoing low mood often points to an underlying medical or hormonal cause that can be addressed.

Hormonal changes play a significant role. In women, falling oestrogen and progesterone levels during perimenopause and menopause can affect mood-regulating neurotransmitters such as serotonin. In men, low testosterone can contribute to fatigue, irritability, and emotional flatness, often referred to as “andropause.”

At Omniya Clinic, we look at the whole picture – hormones, thyroid health, stress, sleep, nutrition and medications – to uncover why you’re feeling low and help you restore balance, clarity and motivation.

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Common Causes of Low Mood

Low mood rarely has a single cause — it’s often the result of several overlapping factors. At Omniya Clinic in Knightsbridge, we look at your hormones, thyroid, nutrition, stress, sleep, and medications to understand what’s driving your symptoms and how best to treat them.

Hormonal Factors

Hormones play a key role in regulating mood, motivation, and emotional balance.

Perimenopause and menopause – changes in oestrogen and progesterone can affect serotonin and dopamine, leading to mood dips, anxiety, and fatigue.
Low testosterone – in men (and sometimes women) can reduce motivation, energy, and confidence.
Underactive thyroid (hypothyroidism) – slows metabolism and often causes tiredness, irritability, and emotional flatness.

Nutritional & Metabolic Factors

Nutrient deficiencies or metabolic imbalances can directly impact brain chemistry and energy.

Low iron, ferritin, vitamin B12, or vitamin D – all essential for healthy neurotransmitter function and energy production.
Blood sugar dysregulation or insulin resistance – can cause energy crashes and irritability.
Dehydration or inadequate protein and fibre – can subtly affect mood and concentration.

Lifestyle & Sleep

The way we live profoundly affects our emotional health.

Poor sleep quality or sleep apnoea – disrupt restorative rest and increase stress hormones.
Long-term stress or burnout – exhausts adrenal and hormonal systems.
Limited daylight exposure or low physical activity – can lower serotonin and worsen mood during darker months.

Medical & Medication Factors

Certain medical conditions and medicines can influence mood regulation.

Post-viral fatigue or chronic inflammation – can alter neurotransmitter balance and increase tiredness.
Side effects from medications – including some antidepressants, hormonal contraceptives, or blood-pressure tablets.
Co-existing anxiety or depressive disorders – may interact with hormonal or metabolic factors.

Because low mood is often multifactorial, our team takes a comprehensive, root-cause approach — combining medical assessment, targeted blood testing, and tailored treatment to help you regain clarity, motivation, and emotional stability.

Female Hormone Replacement Therapy, HRT consultation

Signs It’s Time to Get Checked

Occasional dips in mood are normal, but persistent or worsening symptoms can signal an underlying issue that deserves medical attention. Watch for these signs that it’s time to book a review:

Feeling low or down most days for two weeks or more
Loss of interest or pleasure in activities you normally enjoy, with low motivation or brain fog
Sleep disturbances – difficulty falling asleep, early waking, or insomnia
Low energy, irritability, anxiety, or a sense of overwhelm
Changes in appetite or weight – either loss or gain

What You Can Do Now

Small, consistent habits can have a big impact on mood, energy, and motivation. These evidence-based foundations help regulate hormones, stabilise mood, and support any treatment you choose to pursue.

Sleep: Aim for a regular sleep schedule — go to bed and wake up at similar times each day. Get morning daylight to reset your body clock and create a wind-down routine in the evening. Try to limit caffeine and alcohol later in the day, as both can affect sleep depth and mood regulation.
Movement: Physical activity is one of the most effective ways to lift mood and reduce stress. Include daily movement – whether that’s walking, yoga, or cycling – and, if possible, two strength-training sessions per week to support hormonal and metabolic health.
Nutrition: Eat protein with every meal to stabilise blood sugar, add colourful vegetables for antioxidants, and include fibre-rich foods for gut and brain health. Hydration also matters more than most people realise – aim for steady water intake throughout the day.
Stress Care: Stress and low mood are closely linked. Try short breathwork or mindfulness breaks, get daylight exposure, and talk to trusted people, even brief connection can ease the load.
Medication Review: Never stop prescribed medication abruptly, but do discuss any side-effects with your clinician. Sometimes small adjustments, or addressing underlying hormonal or nutritional factors – can improve both mood and medication tolerance.

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What Treatments Are Available For Low Mood?

Female hormone replacement therapy (HRT) Male hormone replacement therapy (TRT) GP wellness check Weight loss consultation Thyroid therapy Hormones MOT Program Comprehensive gut health analysis

Low Mood FAQs

Why does HRT work with mood?

Stabilising oestrogen/progesterone can improve sleep, vasomotor symptoms, brain fog and overall emotional steadiness in peri/menopause, often lifting mood indirectly and, for some, directly.

Do I have to stop taking HRT after I've been through menopause?

Not automatically. HRT is reviewed regularly and continued only if benefits outweigh risks for you. Many remain on the lowest effective dose and reassess over time.

Can TRT help with erectile dysfunction?

If low testosterone is confirmed and TRT is appropriate, it may improve libido, energy and mood, and can support erectile function alongside other measures where needed.

What kind of mood changes can TRT help with?

When low testosterone is the driver: low motivation, reduced drive, irritability and brain fog may improve under supervised TRT, plus sleep and energy gains.

Will IV drips fix low mood?

They can support hydration/nutrients but are an adjunct. Long-term improvement comes from addressing the underlying causes (hormones, thyroid, iron/B12, sleep, stress, metabolism).