The Benefits Of Testosterone Replacement Therapy (TRT)

Understanding the Role of Testosterone in Men’s Health

Testosterone plays a central role in male vitality, shaping energy levels, muscle strength, mood, and mental sharpness. Yet, as men move into their 40s and beyond, testosterone levels naturally start to decline—typically by around 1-2% each year from the age of 30. This gradual shift can lead to noticeable changes, such as reduced energy, motivation, and muscle tone, weight gain, and alterations in sexual health. While it’s often dismissed as a normal part of ageing, at Omniya Clinic London, we believe that a drop in testosterone doesn’t have to equate to a drop in quality of life.

Guided by cutting-edge clinical research and the experiences of countless patients, our Testosterone Replacement Therapy (TRT) programs are crafted to help men take charge of their health and vitality. Whether it’s about improving physical performance, sharpening mental clarity, or simply feeling more like yourself, TRT is a safe and scientifically supported pathway to living a fuller, more energised life.

Testosterone Replacement Therapy (TRT)

The Benefits of TRT for Energy, Strength, and Weight Management

One of the most immediate benefits men notice with TRT is an increase in energy. The 2024 TRAVERSE study published in The Journal of Clinical Endocrinology & Metabolism observed that men who maintained higher testosterone levels reported less fatigue and improved mood over time(1). This uptick in energy levels doesn’t just lift spirits—it directly impacts daily motivation and productivity, making it easier to tackle both personal and professional demands with vigour.

Muscle Mass and Strength: Testosterone is essential for muscle growth and strength. As levels dip, muscle loss becomes more pronounced, often impacting balance and physical performance. TRT can help reverse this trend. By supporting muscle protein synthesis, TRT aids in preserving lean muscle mass, which is linked to better metabolic health and weight control.

Metabolism and Weight Management: Testosterone plays a key role in fat distribution and metabolism. Research has shown that men with optimal testosterone levels have lower rates of abdominal obesity, a major risk factor for heart disease. By increasing lean body mass and reducing visceral fat—the deep belly fat surrounding organs—TRT can support more effective weight management(2).

TRT and Bone Density

Beyond muscle and metabolism, testosterone affects bone density. Low testosterone is associated with an increased risk of osteoporosis in men, not entirely dissimilarly to how low oestrogen predisposes postmenopausal women to osteoporosis. Reduced bone density weakens the bones, raising the likelihood of fractures. With TRT, men can maintain and even improve bone health, helping prevent bone loss and its associated risks(3).

TRT & Sexual Health

Low testosterone can lead to decreased libido and erectile dysfunction (ED), issues that impact not only physical health but emotional well-being. Studies show quite variable data on the effects of TRT on erectile function, owing largely to the multifactorial nature of ED. A recent review of the literature reported that men undergoing TRT showed a mildly significant improvement in erectile function and sexual satisfaction compared to those not on therapy. An important factor that is not taken into account in most literature is that almost all patients with ED as a consequence of low testosterone have also developed a psychological basis to their ED. By restoring testosterone levels, TRT helps men achieve stronger, more consistent sexual health, but to fullyboost both confidence and quality of life from the sexual standpoint, often psychosexual symptoms require concurrent treatment(4).

Explore our specialised treatments for erectile dysfunction

The Psychological Impact of Testosterone Replacement Therapy

Low testosterone isn’t just a physical issue—it affects mental health too. Men with low testosterone often experience mood swings, irritability, anxiety and even depression. TRT has an important roll in the release of serotonin, an important neurotransmitter in the brain implicated in mood disorders. Whilst not a treatment for depression, studies show that TRT can effectively alleviate symptoms of low mood and anxiety in men with low testosterone, enhancing overall mental resilience and emotional balance(1).

Cognitive Benefits: Testosterone influences cognitive abilities, from memory to focus, with longterm deficiency of testosterone being linked to cognitive dysfunction including dementia. Some research has suggested that TRT can enhance cognitive function, offering a mental boost that supports clearer thinking, better concentration, and sharper recall. There has not been sufficient research done to confirm TRT’s benefits on short and long term cognitive function(5). Despite the equivocal research findings for many men there is a significant improvement in cognitive function, helping them stay mentally agile in all aspects of life.

TRT and Type 2 Diabetes

Research points to a link between testosterone levels and insulin sensitivity, making TRT a potential consideration for men with type 2 diabetes and low testosterone. Studies have found that men with low testosterone undergoing TRT experience improved insulin sensitivity, better control of blood sugar levels and even improvements in triglyceride levels(6). For men with diabetes or prediabetes, there is ever increasing evidence showing that TRT may offer benefits in blood sugar management, reducing the risk of long-term complications. These benefits are only augmented by the increased potential for weight loss once a patient with low testosterone has had their levels of testosterone normalised.

Starting TRT at Omniya Clinic

Your TRT journey with us begins with a consultation and health assessment. We take a holistic approach so we consider everything:

1. Consultation and Assessment: One on one with our clinicians to understand your needs and current health.
2. Personalised Treatment Plan: We use the results of your assessment to create a TRT plan to get your testosterone back to optimal and support your overall health.
3. Ongoing Monitoring and Adjustment: TRT is a journey and we’re with you every step of the way, reviewing and adjusting your treatment as needed to ensure it’s working and aligned with your goals.

TRT FAQs

How long until I see results?

Most men start to notice changes within a few weeks, full benefits typically take 3 months.

Is TRT safe?

When done under medical supervision TRT is safe. Our clinicians are experienced in managing treatment plans and addressing side effects.

Can TRT help with weight loss?

Yes. By increasing muscle mass and metabolism TRT can help with weight management and get you to a healthier body.

Whether you want to regain energy, strengthen your body or improve mental clarity TRT is the path to better health and wellbeing. Our team at Omniya Clinic are here to support you every step of the way with personalised care to help you flourish.

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Reclaim your energy, confidence, and quality of life with Omniya Clinic’s TRT program—where science and compassionate care meet to support men’s health at every stage.

1. Bhasin S; Seidman S; Travison TG; Pencina KM; Lincoff AM; Nissen SE; Miller MG; Flevaris P; Li X; Wannemuehler KA; Pope HG. Depressive Syndromes in Men With Hypogonadism in the TRAVERSE Trial: Response to Testosterone-Replacement Therapy. J Clin Endocrinol Metab. 2024 Aug 13;109(9):e1798-e1799.

2. Lee T, Kao P, Chen Y, Wang S. Effects of Testosterone Replacement Therapy on Muscle Strength in Older Men with Low to Low-Normal Testosterone Levels: A Systematic Review and Meta-Analysis. Gerontology 2023;69:1157–1166.

3. J Finkelstein, A Klibanski, R Neer, S Greenspan, D Rosenthal, W Crowley. Osteoporosis in Men with Idiopathic Hypogonadotropic Hypogonadism. Annals of Internal Medicine. 1987:106:354-361.

4. Xu Z, Chen X, Zhou H, Ren C, Wang Q, Pan Y, Liu L and Liu X. An updated systematic review and meta-analysis of the effects of testosterone replacement therapy on erectile function and prostate. Front. Endocrinol. 15:1335146.

5. Lisco G, Giagulli V, De Tullio A, De Pergola G, Guastamacchia E and Triggiani V. Age-Related Male Hypogonadism and Cognitive Impairment in the Elderly: Focus on the Effects of Testosterone Replacement Therapy on Cognition. Geriatrics 2020, 5, 76; doi:10.3390/geriatrics5040076.

6. Si Hyun Kim, Jae Joon Park, Ki Hong Kim, Hee Jo Yang, Youn Soo Jeon, Sung Ryul Shim, Jae Heon Kim. Efficacy of testosterone replacement therapy for treating metabolic disturbances in late‐onset hypogonadism: a systematic review and meta‐analysis. International Urology and Nephrology (2021) 53:1733–1746.